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Low Libido and Erectile Dysfunction were reported as side effects in hydrochlorothiazide clinical trials for Hydrochlorothiazide. Do not remove micardis hydrochlorothiazide HCT tablets from blisters until right before you take them. Fetal testing may be appropriate, based on the week of pregnancy. Stagger the dosage of hydrochlorothiazide and the resin such hydrochlorothiazide that hydrochlorothiazide is administered at least 4 hours before or 4 to 6 hours after the administration of the resin. From Heart Health Resources Featured Centers Health Solutions From Our Sponsors Report Problems to the Food and Drug Administration You are encouraged to report negative side effects of prescription drugs to the FDA. Keep using this medicine as directed, even if you feel well. Dosage dosage AND administration Dosing Information Initiate a dosage patient whose blood hydrochlorothiazide pressure is not adequately controlled with telmisartan monotherapy 80 mg on micardis hydrochlorothiazide HCT, 80 mg/12.5 mg once daily. Take micardis HCT tablets with or without food. In some cases, Hydrochlorothiazide has caused anaphylactic shock. Four other studies of hypertensive patients of at least six months' duration allowed add-on of hydrochlorothiazide for patients who either were not adequately controlled on the randomized telmisartan monotherapy dose or had not achieved adequate blood pressure response after completing the up-titration of telmisartan. The pharmacokinetics of telmisartan with orally administered micardis are nonlinear over the dose range 20 to 160 mg, with greater than proportional increases of plasma concentrations (Cmax and AUC) with increasing doses. These adverse outcomes are usually associated with use of these hydrochlorothiazide drugs in the second and third trimester of pregnancy. When co-administering telmisartan and ramipril, the response may be greater because of the possibly additive pharmacodynamic effects of the combined drugs, and also because of the increased dosage exposure to ramipril and ramiprilat in the presence of telmisartan. Metabolism Telmisartan is metabolized by conjugation to form a pharmacologically inactive acyl glucuronide; hydrochlorothiazide the glucuronide of the parent compound is the only metabolite that has been identified in human plasma and urine. Diuretics such as triamterene can raise your blood potassium to dangerous levels. The no-observed effect doses for developmental toxicity in rats and rabbits, 5 and 15 mg/kg/day, respectively, are approximately.64 and.7 times, respectively, on a mg/m dosage basis, the mrhd of telmisartan (80 mg/day). Telmisartan blocks the vasoconstrictor and aldosteronesecreting effects of angiotensin II by selectively hydrochlorothiazide blocking the binding of angiotensin II to the AT1 receptor in many tissues, dosage such as vascular smooth muscle and the adrenal gland. No drug-related effects on the reproductive performance of male and female rats were noted at 100 mg/kg/day (the highest dose administered about dosage 13 times, on a mg/m basis, the mrhd of telmisartan. Medication Guide patient information micardis HCT (my-CAR-dis HCT) (telmisartan and hydrochlorothiazide ) Tablets Read this Patient Information before you start taking micardis HCT tablets and each time you get a refill. What is high blood pressure (hypertension)? Revised: Jan 2016 Side Effects side effects The following adverse reactions are discussed dosage elsewhere in labeling: Clinical Trials Experience dosage Because clinical studies are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies. Diuretics such as Hydrochlorothiazide may cause or aggravate pancreatitis. Tablets should not be removed from blisters until immediately before administration. At least 61 of the oral dose is eliminated unchanged within 24 hours. It may harm them. This list is not complete. Call your doctor at once if you have: a light-headed feeling, like you might pass out; eye pain, vision problems; jaundice (yellowing of the skin or eyes pale skin, easy bruising, unusual bleeding (nose, mouth, vagina, or rectum shortness. Do not use potassium supplements, salt substitutes, or low-sodium milk unless your doctor has told you. Store micardis HCT tablets between 59F to 86F (15C to 30C). Take the missed dose as soon as you remember. Hypotension In Volume- Or Salt-Depleted Patients In patients with an activated renin-angiotensin system, such as volume- or salt-depleted patients (e.g., those being treated with high doses of diuretics symptomatic hypotension may occur after initialization of treatment with micardis HCT.

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